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Sandborn WJ, Rutgeerts P, Feagan BG, et al

But when levels drop, your body notices fast

We know that B12 recovery from bile would be a problem but this only contributes 5mcg to the picture, so I think its an open question

Individual Variability: Depending on factors such as age, baseline cognitive level, and metabolic capacity, different users may perceive significant effects at any point between 4 and 8 weeks

According to Ghiyam, researchers were particularly concerned about uncontrolled darkening of existing moles and other pigmentation changes, which contributed to the decision not to approve the drug