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During the late 1990s and early 2000s, it was suggested that one of the three precursors, IGF-1EC (MGF), may increase upon muscle injury

The logic here is that the human body releases growth hormone in natural pulses with gaps in between, and this schedule more closely mimics that rhythm

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This yielded to conflicting results, raising questions about whether PN could be a direct consequence of their interaction or an additional systemic feature of PD on which B12 deficiency can act as a negative predictive factor (Comi et al

doi: 10.1038/s41419-020-03194-2 57 XuTDingWJiXAoXLiuYYuWet al