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Cell Reports , 44 (4), 115529 Yang, L., Chu, Z., Liu, M., Zou, Q., Li, J., Liu, Q., Wang, Y., Wang, T., Xiang, J., & Wang, B

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These neurons respond to oxidative signaling from reactive oxygen species (ROS) generated during normal cellular metabolism

Neuroinflammation and neurotoxic KP metabolites like QUIN suppress neurogenesis in the adult hippocampus and reduce levels of Brain-Derived Neurotrophic Factor (BDNF), a molecule essential for neuronal survival, growth, and plasticity ( 4 Clinical evidence of the association between IBD and depression The mechanistic link between intestinal inflammation and brain dysfunction is strongly corroborated by a robust body of clinical and epidemiological evidence