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According to molecular profiling, BC is a heterogenous disease including different subtypes ( Ins and IGF system comprises a complex intracellular network intricates in cell metabolism, differentiation, and survival and displays a crucial role in several tumors, including BC ( The role of IRs in cancer, including BC, has been reported and related to IRs ability to improve tumor progression and chemoresistance, and to modulate the cancer stemness ( About 70% of all BC express high levels of ER based on its expression by immunohistochemistry approach

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Tip 4: Switch it up