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Foundayo (Orforglipron) Foundayo is a newer, non-peptide oral GLP-1 receptor agonist, convenient for daily use without special storage needs, making it an appealing choice for many seeking simpler therapy options

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SUMMIT: Tirzepatide and heart failure with preserved ejection fraction SUMMIT (Packer et al., NEJM 2024, NEJMoa2410027, PMID 39555826) randomized 731 patients with heart failure with preserved ejection fraction (HFpEF) and a BMI 30 to tirzepatide up to 15 mg/week or placebo, with a median follow-up of 104 weeks

Weight loss from GLP-1 therapy includes some loss of lean body mass, with studies suggesting that approximately Short-term clinical trials have generally shown preserved muscle strength despite reductions in lean mass, and some studies suggest these medications may improve muscle quality by reducing fat infiltration within muscle tissue

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