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Al-Majed AA, Sayed-Ahmed MM, Al-Yahya AA, Aleisa AM, Al-Rejaie SS, Al-Shabanah OA: Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model

Its generally considered safe to do so, provided you stay well below the upper limit of 40 mg daily, which can be toxic

Plus, rapid weight loss (more than about 3 pounds per week sustained) is associated with greater muscle loss, a higher risk of nutrient deficiencies, an increased risk of gallstones, and a much higher likelihood of regaining weight afterward

GLP-1RA therapy was associated with reductions in total cholesterol, low-density lipoprotein cholesterol and triglyceride levels compared with placebo or other hypoglycaemic agents

Examples include brisk walking, cycling, or swimming at 50-70% maximum heart rate