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Further mechanistic studies suggest that the cardioprotective effects of APS may be mediated by the regulation of the PI3K/Akt/mTOR signaling pathway, which is essential for maintaining cardiomyocyte survival, regulating autophagy, and inhibiting apoptosis ( 60 Co- irradiation in mice, achieving its protective effect by promoting the secretion of IFN- and interleukin-4 (IL-4) (Zhao et al., 2015)

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