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2003;9(3) [PubMed: 12952754] [CrossRef] 199

Cartilage, ligaments, and surrounding tissues must adapt to reduced load, and this transition can trigger inflammatory signaling and temporary discomfort, especially in weight-bearing joints like knees, hips, and ankles

Correspondingly, both -phe1 analogues exerted superior anti-hyperglycaemic effects in an IPGTT performed 8 hours after agonist administration, with exendin-phe1 being the most effective (Figure 6I)