Such knowledge could inform the design of precision therapies that restore mitochondrial homeostasis in a tissue-specific manner while minimizing systemic side effects
Mol Psychiatry 28:284297 Frost G, Sleeth ML, Sahuri-Arisoylu M, Lizarbe B, Cerdan S, Brody L, Anastasovska J, Ghourab S, Hankir M, Zhang S, Carling D, Swann JR, Gibson G, Viardot A, Morrison D, Louise Thomas E, Bell JD (2014) The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism
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It is because they create a larger gap between medicated and unmedicated metabolic states
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