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Additionally, patients with inflammatory bowel disease, severe gastroesophageal reflux disease, or other significant gastrointestinal disorders should be monitored closely if treatment is initiated, as the gastrointestinal effects of semaglutide may worsen their underlying condition

wobei TFA, PhSMe, PhOMe, EDT, H 2 O, TIS und PhOH in einem Volumenverhltnis von 80-90: 0-5: 0-3: 0-5: 0-5: 0-2: 0-5 vorliegen

In one embodiment of the present invention, the reaction pH in the step (1) is 10 to 12, and the pH at the isoelectric point of the reaction solution is adjusted to 4 to 6

2.17 g of DMAP was added, and stirred with air-blowing for 2 h