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Schjoedt KJ, Christensen PK, Jorsal A et al (2009) Autoregulation of glomerular filtration rate during spironolactone treatment in hypertensive patients with type 1 diabetes: a randomized crossover trial

These two conflicting observations can be reconciled by the fact that most of these necessary changes involve DV, which is buried in the prefusion conformation structure, severely limiting the possible target area

doi: 10.1186/s13229-018-0218-4 8 BertuccioM

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Standard dosing ranges from 2-5mg administered subcutaneously two to three times weekly