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TB-500 is a synthetic fragment of thymosin beta-4, an actin-binding peptide that promotes cell migration and tissue repair (Goldstein et al., 2012)

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That adipose-specific NNMT knockdown protects against diet-induced obesity in mice through mechanisms involving increased adipocyte energy expenditure

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Rather, it reflects the evidence available, how the compound is manufactured and distributed, and whether regulators believe it should be available through established medical channels