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So, when you lose weight rapidly or have a calorie deficit for an extended period of time, your body thinks that youre going through a period of famine

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This metabolic imbalance contributes to increased lipid peroxidation, as indicated by high malondialdehyde (MDA) levels ( These mitochondrial impairments not only compromise energy production but also act as pro-inflammatory stimuli, promoting chronic neuroinflammation through dysregulated mitochondrial signaling and innate immune response