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10.1056/NEJM199108293250902 [DOI] [PubMed] [Google Scholar] 70.Hansen PS, Brix TH, Iachine I, Kyvik KO, Hegedus L

In the central nervous system, the action of GLP-1 and GLP-1RAs on its receptors can affect a variety of brain functions including satiety, thermogenesis, influence blood pressure, neurogenesis, neurodegeneration, retinal repair, and change energy homeostasis [16-20]

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Documented in the literature are insulin resistance and impaired glucose tolerance, fluid retention with edema, joint pain, and carpal-tunnel-type paraesthesias

The issue is these individuals have a set-point weight that the body is trying to get back to every time weight loss occurs