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Akkermansia muciniphilia (A muciniphilia) is an intestinal anaerobe which finds itself in the human digestive tract very early on in life [7]

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The most commonly reported side effects include: Nausea and vomiting particularly during dose escalation Diarrhoea or constipation affecting bowel regularity Abdominal pain and bloating related to delayed gastric emptying Dyspepsia indigestion or upper abdominal discomfort Headache especially during initial treatment Fatigue and dizziness especially in the initial treatment phase Injection site reactions such as redness or irritation These gastrointestinal effects typically diminish over time as the body adjusts to the medication

This proactive approach enables doctors to intervene sooner, tailoring GLP-1 dosing to maximize therapeutic outcomes

Control: control group with saline at the same volume