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Depression: Chronic tobacco use alters brain chemistry, increasing depression risk and diminishing pleasure experience

A Guide To Nicotine Gum Side Effects - Conclusion Nicotine gum is a safer alternative to consume nicotine than smoking, but it could also serve as one tool in your arsenal to combat smoking cravings and triggers

PMID 14512270

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Smoking directly affects the arteries, which results in atherosclerosis (the constriction of the arteries as a result of plaque development) and is blamed for this higher risk