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345 Co-activator involvement in different cancers A rampant occurrence With the rising burden of cancer, it has become imperative to develop new therapeutic approaches to curb disease progression

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Lien S, Larsson AK, Mannervik B

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Red flags No COA available or refuses to provide one Prices significantly below market range (quality testing is expensive) Vials arrive without proper labels or lot numbers The powder looks discolored or has a strange odor after reconstitution The solution remains cloudy after 30 minutes of gentle mixing With the bulk tirzepatide market growing rapidly, counterfeit and under-dosed products do exist

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10.1136/gutjnl-2013-305112 27

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ATZ was observed to downregulate key steroidogenic enzymes, including 3-HSD and Cyp17a1 , and disrupt the expression of genes critical for testosterone production, such as StAR 8,9,10

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