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23 reported that smokers exhibited significant changes in caffeine metabolism relative to non-tobacco consumers based on metabolomic analysis

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Quality assessment Of the 12 human studies, 6 (50%) had a low risk of bias 16,20,24,30,32,38 , 5 (41.7%) had some concerns or moderate risk 14,15,19,21,23 , and 1 (8.3%) had a very high risk of bias 17