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Initial applications favored topical and local repair

Metformin increased postprandial GLP-1 secretion compared with placebo (P = 0.014), and the postprandial glucose excursions were significantly smaller after metformin + saline compared with metformin + Ex9-39 (P = 0.004)

This gap exists primarily because of the dramatic bioavailability difference

Thus, a reduction of this N-terminal peptide bond rendered peptides significantly less prone to hydrolysis

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