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Luzindole (LUZ) is a widely used non-selective antagonist of the melatonin receptors MT1 and MT2, enabling us to test whether the effects of exogenous melatonin were receptor-mediated (38, 39)

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Notably, other related biomarkers like isofurans (IsoFs), which are preferentially formed under high oxygen tensions, complement F2-IsoPs by providing additional information about oxygen-dependent lipid peroxidation (Milne et al., 2013)

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