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doi: 10.1681/asn.2016030374 78 ShiH

When multiple publications addressed similar experimental models or clinical populations, priority was given to studies with larger sample sizes, standardized extracts, rigorous study designs, and clearly reported outcomes

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TB-500 has been particularly extensively studied in cardiac repair models with foundational research demonstrating that thymosin beta-4 and TB-500 promote cardiomyocyte survival following ischaemia-reperfusion injury, stimulate cardiac progenitor cell migration into infarcted tissue, reduce infarct size, and improve cardiac function in myocardial infarction models