Nicotine withdrawal can lead to increased cravings for food and weight gain, making it difficult for some to maintain their quit attempt
Springer Netherlands, pp 261315
Additionally, GLP-1 RAs may influence other epigenetic regulators, such as sirtuins and histone deacetylases, which play a role in crucial cellular functions like inflammation and stress response
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[ At our Plymouth clinic, we look for specific clinical markers before discussing any taper: Sustained target weight reached and maintained for a minimum of three to six months Stable fasting glucose and HbA1c at goal if applicable No active comorbidities being driven by unmanaged obesity Demonstrated behavioral patterns consistent nutrition, physical activity, and stress management that are likely to persist off medication When these criteria are met, a supervised weaning conversation begins
