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For instance, liraglutide significantly reduced cerebral A plaque burden in APP/PS1 mice and enhanced spatial learning and memory.124 Similarly, semaglutide reduces A deposition, improves cognition, and attenuates neuroinflammation by activating AMP-activated protein kinases and inhibiting the Toll-like receptor 4/nuclear factor kappa B signaling pathway.124 The dual GLP-1/GIP receptor agonist tirzepatide ameliorated AD pathology in diabetic rat models by improving learning and memory, modulating cerebral glucose metabolism, promoting neurotrophic factor expression, and suppressing inflammatory responses.125 Collectively, these findings suggest that GLP-1RAs and GLP-1/GIP dual receptor agonists are promising disease-modifying agents for AD

Brood size and development assay For the brood size assay, an individual animal at the L4 stage was picked onto one NGM plate seeded with 200 L bacteria grown under the conditions used in the behavioral assay

SynonymsSeville orange, Bitter orange, Bigarade orange, and Aurantium acre mill

no human evidence supports a clinically significant effect on estrogen production

Non-neuronal cholinergic system in human bladder urothelium