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Tip: Semaglutide has a 7-day half-life (the longest among GLP-1s), meaning it takes 4-5 weeks to reach steady state at each dose tier

Even at high summer temperatures, peptides in lyophilized form remain stable for several weeks

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The FDA added it to injectable semaglutide in January 2025, and it climbs the dose axis like everything else. Burning or tingling skin tracks the dose, not the weight lost, and an active-comparator study put the risk about twice that of another weight-loss drug. The mechanism is unsettled: the tempting "it is the drugs signaling arm" story is ruled out, because the strongest GLP-1 signaler in the class carries no such signal