tirzepatide as compared with semaglutide for the treatment of obesity on ingestive behavior in adults overweight or obesity: a randomized 6-week phase 1 trial Semaglutide vs. Tirzepatide for Weight

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This suggests both a weight loss-independent effect of tirzepatide, mediated by GIP and GLP-1 receptor agonism as demonstrated by an increase in pancreatic beta-cell glucose sensitivity and enhancing insulin secretion, and other weight loss-dependent effects such as waist circumference

Instead, electrophysiological and behavioral experiments suggest that exendin-4 increases the activity of ventral striatal neurons and reduces food intake, respectively, via presynaptic GLP-1 receptors in glutamatergic neurons and subsequent postsynaptic AMPA receptor activation [103], analogous to the aforementioned mechanism in the VTA [99]

Matthay KK, Maris JM, Schleiermacher G, Nakagawara A, Mackall CL, Diller L, et al