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Native human amylin is strongly amyloidogenic, which is why it cannot be formulated directly and why fibrillation is the central design constraint described by Kruse and colleagues (J Med Chem, 2021)

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Im going to suggest that the line between #1 (minor tear) and #2 (moderate tear) is when youre facing a partial thickness tear thats between 20-40% If your tear is less than 20% you may have a decent chance of healing without surgery or more aggressive measures