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Currently, effective therapies for ALS are lacking

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2 Neuroinflammation in depressive disorder: multidimensional pathogenic mechanisms Neuroinflammation is an evolutionarily conserved defense mechanism in the CNS, triggered by insults such as infection or injury and mediated through the coordinated activation of resident glial cells and recruited immune cells (Kopp et al., 2022)

One of these antioxidant defense systems is the glutathione antioxidant pathway, which includes the enzymes GPx, GST and GR, together with GSH metabolite