Seek endocrine evaluation if you experience progressive central weight gain with easy bruising, proximal muscle weakness, wide purple striae, resistant hypertension, unexplained osteoporosis, or hypokalemia
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Early-stage data hint that the next wave could push weight loss into territory once only achievable with bariatric surgery
Endpoints and subgroup analysis Outcomes of interest were: body weight, body mass index (BMI), weight reduction of 5 %, weight reduction of 10 %, weight reduction of 15 %, weight reduction of 20 %, waist circumference, daily mean blood glucose, glycated hemoglobin (HbA1c), fasting glucose, fasting insulin, fasting C-peptide, glucagon, systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), amylase, lipase, treatment-emergent adverse events (TEAEs), serious adverse events, pulse rate, deaths, TEAEs leading to study treatment discontinuation, diarrhea, nausea, vomiting, constipation, abdominal pain, dyspepsia, gastroesophageal reflux, headache, dizziness, hypersensitivity, hepatic or biliary disease, severe gastrointestinal adverse events, major adverse cardiovascular events, injection site reaction, cardiac arrhythmias
Enriched gene functions and canonical biological pathways were identified with Ingenuity Pathways Analysis software (Ingenuity Systems, Redwood City, CA, USA) using Fishers exact test
