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In this pathway, the transcription of p53 activates the expression of pro-apoptotic proteins Bax/Bak and inhibits the expression of anti-apoptotic proteins Bcl-2/Bcl-xL, resulting in increased mitochondrial membrane permeability and cytochrome c release, which in turn activates the caspase-9/3 cascade reaction and ultimately causes apoptosis (Aranda-Rivera et al., 2021

Growth hormone plays a crucial role in collagen synthesis, which is essential for maintaining skin elasticity and reducing the appearance of wrinkles and fine lines

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