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After a failed attempt in the 1990s and early 2000s, backed by an enormous advertising push to convince the smoking public that switching to smokeless tobacco or the newly introduced product, snus, would be a better alternative for enjoying tobacco (based on what was called the Swedish experience, which has never been replicated elsewhere), harm reduction proponents became intrigued with the even newer electronically heated nicotine vapor products that emerged from China

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This is one of the reasons why nicotine gum has become so popular in recent years

In May, 22nd Century announced that the FDA had authorized the company to conduct a clinical trial of its "Brand B" low tar-to-nicotine cigarettes, made of a proprietary high-nicotine blend