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Finally, enrichment analysis of the significant signal transduction pathways based on the differential metabolites was carried out using KEGG

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These results align with the Bienenstock-Cooper-Munro (BCM) model for maintaining network stability and the rebound effect phenomenon (Rahman et al., 2013)

Subsequent drug supplementation experiments indicated that enhancing GSH/GPX antioxidant activity could treat SAH and provide neuroprotection (Handa et al., 2000