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Psychological comorbidity in gastrointestinal diseases: update on the brain-gut-microbiome axis

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Compared to other similar cases reported in the literature and treated with transurethral resection (TUR)/cystectomy and that had synchronous metastases, our patient has a good PS and demonstrated a progression free survival (PFS) of almost 48 months (Table 1)

Weight loss trajectory was still accelerating Phase 1 (oral): 10.4-13.1% weight loss at 12 weeks depending on dosing regimen vs 1.2% placebo Phase 2 (T2D): SC amycretin showed up to 14.5% weight loss and HbA1c reductions up to 1.8% at 36 weeks

This increase correlated with a significant reduction in the amount and expression of PVY NTN and the induction of the HR response