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The effect of IL-17 on BBB disruption has been thoroughly documented (35, 59)
2022;257 doi: 10.1016/j.physbeh.2022.113967
Neurofibromatosis type 1 (NF-1) is a risk factor for developing MPNSTs
83 However, within the tumor niche, cancer cells, MDSCs, TAMs, suppressive DCs, and cancer-associated fibroblasts, among other cell types, exhibit upregulated expression of indoleamine 2,3-dioxygenase (IDO), which metabolizes tryptophan into suppressive kynurenine to promote Tregs and suppress CD8 + T cell function
Proc Natl Acad Sci 111(37):1355913564 Fdingeer M, Wagner OF, Hrl WH, Sunder-Plassmann G (2001) Recent insights into the molecular genetics of the homocysteine metabolism
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