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Beyond the numbers, tirzepatides dual mechanism of action (working on both GIP and GLP-1 receptors) gives it an advantage in appetite control and metabolic improvement

Polycystic ovary syndrome (PCOS) represents a clinical scenario where tirzepatide's metabolic effects may have particular relevance to fertility, though this remains an area requiring further research

The pleiotropic effects of GLP-1 receptor agonists across seven or more organ systems are not a feature that future computation will simply solve

It doesn't speed up or slow down weight loss

Advocates like the Alzheimers Association are not fully abandoning their hopes that GLP-1 therapy for Alzheimers can help, at least not yet